Academy Award-winning actor George Clooney is now in talks to star in Up in the Air according to Variety. Air is an adaptation of George Kirn's novel about a corporate downsizer whose life revolves around collecting air miles. While Jay Roach was once in line to direct the film, those duties will now be given to Jason Reitman (Juno). Clooney's Burn After Reading recently premiered at the Venice Film Festival and it hits theatres on September 12.